ATAXIL (PACLITAXEL) 300MG 50ML VIAL

Ataxil contains paclitaxel, one of the most widely used chemotherapy medicines in the world. It belongs to a group called taxanes, which work by stopping cancer cells from dividing and multiplying. Paclitaxel is used to treat: ovarian cancer (primary and recurrent), breast cancer (early and advanced/metastatic), non-small cell lung cancer (NSCLC), and AIDS-related Kaposi sarcoma. It is given as an intravenous (IV) drip in a hospital or cancer centre.

This medicine is prepared and administered by trained healthcare professionals only — it is NOT a medicine you take at home. Before each infusion, you will receive pre-medications (including a steroid, an antihistamine, and an acid-reducing drug) to reduce the risk of allergic reactions. The infusion is given over 3 or 24 hours depending on your cancer type and treatment plan, typically every 3 weeks. Doses are calculated based on your body surface area (height and weight).

Not to be used if: white blood cell count (neutrophils) is too low before treatment. Severe allergic reaction to paclitaxel or to Cremophor EL (the carrier oil in the solution) in the past. Pregnancy (harmful to unborn babies) or breastfeeding.

Cisplatin: paclitaxel should be given BEFORE cisplatin to reduce toxicity. Certain antifungals (ketoconazole), antibiotics, and other chemotherapy agents can alter paclitaxel levels — your oncologist will review all medications. Avoid live vaccines during chemotherapy. Apalutamide significantly reduces paclitaxel effectiveness.

Unopened vials: store at 20°C–25°C (room temperature). Diluted solution is stable for up to 27 hours at room temperature. Must be prepared in glass or polypropylene containers — NOT plastic PVC bags. Administer through non-PVC tubing with an in-line 0.22-micron filter.

Paclitaxel is given as a drip in hospital — it is not a tablet or home injection. You will be in the hospital or cancer clinic for several hours on treatment days. Your hair is very likely to fall out, but it will grow back after treatment ends. Blood tests before each cycle check that it is safe to proceed. Tell your oncologist or nurse immediately about any tingling/numbness in your hands or feet, fever or chills (could mean infection), difficulty breathing, or chest pain. Avoid contact with people who have infections. Do not become pregnant during treatment.

11. FREQUENTLY ASKED QUESTIONS

Q: Will I lose my hair on paclitaxel?

A: Yes — hair loss (alopecia) is very common with paclitaxel and affects almost all patients. This includes hair on your head, eyelashes, eyebrows, and body hair. The good news is that hair almost always grows back after treatment is completed.

Q: How is paclitaxel given?

A: Paclitaxel is given as an intravenous (IV) drip through a vein — usually into a port, PICC line, or peripheral vein. You will sit or lie in a reclining chair in the cancer centre. Each infusion takes 3–24 hours depending on your treatment plan.

Q: What is the pre-medication for paclitaxel and why is it needed?

A: Before each paclitaxel infusion you receive a steroid (dexamethasone), an antihistamine (diphenhydramine), and a stomach acid blocker (cimetidine or ranitidine). These reduce the risk of an allergic reaction, which can be severe.

Q: What does peripheral neuropathy from paclitaxel feel like?

A: Peripheral neuropathy is tingling, numbness, burning, or weakness in the hands and feet. It is caused by paclitaxel affecting the nerve fibres. Always report it to your oncologist — your dose may be reduced to prevent it from becoming permanent.

Q: Is it safe to be around family members after a paclitaxel infusion?

A: Yes, paclitaxel is not radioactive and you are not a danger to others at home. However, avoid contact with anyone who has an active infection or illness, as your immune system will be weakened during treatment.