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3. What Is ORIGINAL PIRITON SYRUP and What Is
It Used For? |
What Is ORIGINAL PIRITON SYRUP?
Original Piriton Syrup contains Chlorphenamine Maleate, one of the most trusted and long-established first-generation antihistamines in the world.
It works by blocking histamine H1
receptors, the sites on cells that histamine binds to when an allergic reaction
is triggered. By blocking these receptors, Chlorphenamine stops histamine from
causing the sneezing, runny nose, watery eyes, skin rashes, and itching that
characterise allergic reactions.
As a first-generation
antihistamine, Chlorphenamine Maleate also crosses into the brain, which is why
it causes drowsiness, a side effect that can actually be useful at night or in
situations where itching is preventing sleep.
What Is It Used For?
Piriton Syrup is a household
medicine used throughout Kenya for a wide range of allergic symptoms. It
provides relief from hay fever (pollen allergy), allergic rhinitis (runny nose
and sneezing from various allergens), hives (urticaria, itchy raised skin
welts), allergic skin rashes from food, medicines, or contact allergens,
itching from insect bites and stings, chickenpox itch, and allergic symptoms
accompanying the common cold.
The syrup formulation is particularly useful for children and for adults who have difficulty swallowing tablets.
The familiar Piriton name and GSK-quality assurance make Original
Piriton Syrup a trusted choice for families managing everyday allergic
conditions.
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4. How to Take This Medicine |
Adults and Children over 12
5–10ml (2–4mg) every 4–6
hours. Maximum 40mg (100ml) in 24 hours.
Children 6–12 years
5ml (2mg) every 4–6 hours.
Maximum 20mg (50ml) in 24 hours.
Children 2–6 years
2.5ml (1mg) every 4–6 hours.
Maximum 6mg in 24 hours.
Under 2 years
Not recommended without medical
advice. Consult a doctor before giving to infants.
With or Without Food
Can be taken with or without
food. If nausea occurs, take with food.
Measuring
Use the measuring cup or spoon
provided, household teaspoons vary in size and may not be accurate.
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5. Side Effects |
Common Side Effects
· Drowsiness
(very common, can be useful at night but impairs driving and concentration
during the day)
· Dry
mouth
· Thickening
of respiratory secretions
· Dizziness
· Difficulty
urinating (especially in elderly men)
Uncommon Side Effects
· Blurred
vision
· Headache
· Nausea
· Paradoxical
excitement in children (hyperactivity rather than sedation, especially in young
children)
· Constipation
Serious Side Effects, Seek Immediate Medical Attention
· Severe
allergic reaction to chlorphenamine (rare, seek emergency care)
· Anticholinergic
crisis in overdose (especially in children, seek emergency care immediately)
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6. Contraindications |
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⚠ The following
patients should NOT use this medication: • Hypersensitivity to chlorphenamine or related antihistamines • Acute asthma attack (antihistamines can thicken secretions, use
bronchodilators first) • Concurrent use of MAO inhibitors (MAOIs), or within 14 days of
stopping an MAOI • Narrow-angle glaucoma • Urinary retention (prostatic hypertrophy in men) • Neonates and premature infants
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7. Safety Warnings and Special Precautions |
· DROWSINESS:
Piriton causes significant drowsiness, do not drive or operate machinery after
taking it.
· CHILDREN:
Paradoxical excitability (hyperactivity instead of drowsiness) can occur in
young children, monitor after first dose.
· OVERDOSE
RISK IN CHILDREN: Antihistamine overdose in young children is a medical
emergency, store out of reach and measure doses accurately.
· ELDERLY:
Higher risk of urinary retention, confusion, and falls, use the lowest
effective dose.
· ALCOHOL:
Avoid alcohol, dramatically worsens sedation.
· ASTHMA:
Not recommended during acute asthma, may worsen breathing by thickening
secretions.
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8. Drug Interactions |
Alcohol:
Dramatically increases sedation, avoid
completely.
CNS
depressants (benzodiazepines, opioids, sedatives): Additive
sedation, use with caution.
MAO
inhibitors: CONTRAINDICATED, wait at least 14 days
after stopping MAOIs.
Anticholinergic
drugs (bladder relaxants, some antidepressants): Additive
anticholinergic effects (dry mouth, urinary retention, constipation).
Tricyclic
antidepressants (amitriptyline, nortriptyline): Additive
sedation and anticholinergic effects.
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9. Storage Instructions |
· Store
below 25°C in a cool, dry place.
· Keep
away from direct sunlight.
· Keep
the bottle tightly closed after use.
· Keep
out of reach of children.
· Do
not use after the expiry date.
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10. Prescription Status in Kenya |
Original Piriton Syrup is an
over-the-counter (OTC) medicine available at Pharmily without a prescription.
It is suitable for adults and children over 2 years for common allergic
symptoms. For children under 2 and patients with complex medical conditions, a
pharmacist's or doctor's advice is recommended.
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11. Patient Guidance |
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💊 Key Points
for Patients: ✔ Measure your dose carefully using the
provided measuring device, not a household spoon. ✔ Piriton will make you sleepy, do not
drive or operate machinery after taking it. ✔ Avoid alcohol while taking Piriton, the
drowsiness will be much worse. ✔ For children, watch for paradoxical
reactions (unusual hyperactivity or excitement), if this happens, contact
your pharmacist or doctor. ✔ Store the bottle safely out of reach
of children, antihistamine overdose in children is a medical emergency. ✔ If symptoms do not improve after 5–7
days, or if you develop a rash, difficulty breathing, or swelling of the face
or throat, seek medical attention.
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12. Pharmacist / Prescriber Notes |
Original Piriton Syrup
(Chlorphenamine 2mg/5ml) is a first-generation H1 antihistamine, the GSK
original brand is preferred by many Kenyan consumers for reliability. The
primary counselling points are: sedation (do not drive), alcohol avoidance,
accurate paediatric dosing, and the risk of paradoxical excitation in young
children.
For elderly patients, screen
for glaucoma, BPH/urinary symptoms, and concurrent anticholinergic medications
before recommending. The MAOI interaction is absolute, check for patients on
phenelzine, tranylcypromine, or similar agents.
If daytime sedation is a
concern, recommend a non-sedating second-generation antihistamine (cetirizine,
loratadine) for daytime use and reserve Piriton for night-time itch management.
Antihistamine overdose in children is a paediatric emergency, always counsel on
safe storage and accurate measurement.
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13. Frequently Asked Questions (FAQs) |
Q1: What is Original Piriton Syrup used for?
A: Piriton Syrup is used to
relieve allergic symptoms including hay fever, itchy skin rashes, hives, insect
bites, and allergic reactions causing sneezing, runny nose, and watery eyes. It
is suitable for adults and children.
Q2: Why does Piriton make you sleepy?
A: Chlorphenamine in Piriton
is a first-generation antihistamine that crosses into the brain, causing
drowsiness as a side effect. This can actually be helpful at night, but means
you should not drive or do anything requiring concentration after taking it.
Q3: What is the correct Piriton dose for my child?
A: Children aged 6–12: 5ml
(2mg) every 4–6 hours. Children aged 2–6: 2.5ml (1mg) every 4–6 hours. Children
under 2: consult a doctor before giving. Always use the measuring device
provided, not a kitchen spoon.
Q4: Can I take Piriton for a cold?
A: Piriton can help with runny
nose and sneezing related to the cold, but it does not treat the cold virus. It
thickens respiratory secretions, so if you have a productive cough or breathing
difficulties, discuss with a pharmacist first.
Q5: Can I drive after taking Piriton?
A: No, Piriton causes
significant drowsiness. Do not drive, operate machinery, or do anything
requiring full alertness after taking Piriton. If daytime use without sedation
is needed, ask your pharmacist about a non-drowsy antihistamine option.
Q6: Is Original Piriton Syrup safe for babies?
A: Piriton Syrup is not
recommended for infants under 2 years without medical advice. For children
under 2 with allergic symptoms, consult a doctor or pharmacist for an
appropriate recommendation.
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