GLYSIT 10MG TABLETS 28S

What Is GLYSIT 10mg?

Glysit 10mg contains Dapagliflozin at the 10mg strength, the standard maintenance dose of this SGLT-2 inhibitor. It works in a uniquely simple way: it tells your kidneys to stop reabsorbing excess glucose and instead pass it out through your urine. This lowers blood sugar without triggering insulin release, which means it carries a very low risk of causing hypoglycaemia on its own.

Beyond blood sugar, Dapagliflozin has demonstrated impressive benefits for the heart and kidneys, reducing hospitalisation for heart failure and slowing the decline of kidney function in patients with chronic kidney disease.

What Is It Used For?

Glysit 10mg is used in adults with Type 2 Diabetes to lower blood sugar and HbA1c as part of a comprehensive diabetes management plan. At the 10mg dose, it also provides its full cardiovascular and renal protective benefits, making it the preferred strength for patients with established heart disease, heart failure, or chronic kidney disease.

Glysit 10mg is used alongside lifestyle changes and other diabetes medicines such as Metformin, or as monotherapy when Metformin is not tolerated. In Kenya, Glysit 10mg is increasingly prescribed for the triple benefit, blood sugar, heart, and kidney protection, especially in the growing population with diabetes and hypertension.

Usual Dose

1 tablet (10mg) once daily, preferably in the morning, with or without food.

Timing

Morning dosing is preferred to avoid increased night-time urination.

Before Surgery / Illness

Stop Glysit at least 3 days before any planned surgery or during serious illness, prolonged fasting, or inability to eat. Resume only when your doctor confirms it is safe.

Missed Dose

Take as soon as remembered. If nearly time for the next dose, skip the missed one. Do not double up.

Renal Monitoring

eGFR must be checked before starting and regularly during treatment.

Common Side Effects

·       Increased urination

·       Genital fungal infections (thrush, especially in women)

·       Urinary tract infections

·       Mild dizziness or light-headedness (from fluid loss)

Uncommon Side Effects

·       Back pain

·       Nausea

·       Elevated cholesterol levels

Serious Side Effects, Seek Immediate Medical Attention

·       Diabetic Ketoacidosis (DKA), can occur even with near-normal blood sugar (euglycaemic DKA)

·       Fournier's Gangrene (rare but serious infection of the genitals/perineum, seek emergency care)

·       Acute kidney injury (especially if dehydrated)

·       Lower limb complications (monitor circulation in feet)

·       DKA RISK: Stop Glysit before elective surgery, prolonged fasting, or serious acute illness. Euglycaemic DKA can develop with near-normal glucose levels, symptoms include nausea, vomiting, abdominal pain, confusion.

·       HYDRATION: Maintain good fluid intake, especially in hot weather, SGLT-2 inhibitors have a diuretic effect.

·       FOOT CARE: Inspect feet daily. Report any sores, ulcers, or infections promptly.

·       GENITAL HYGIENE: Maintain good genital hygiene to reduce risk of fungal infections.

·       RENAL: Monitor kidney function regularly. Efficacy for blood sugar lowering is reduced in significant kidney impairment.

Insulin / Sulphonylureas: Increased hypoglycaemia risk, dose reduction may be needed.

Diuretics: Additive fluid and electrolyte loss, monitor for dehydration.

NSAIDs: Increased renal risk.

Rifampicin: Reduces dapagliflozin efficacy.

·       Store below 30°C in a cool, dry place.

·       Keep in original blister packaging.

·       Protect from moisture and light.

·       Keep out of reach of children.

Glysit 10mg is a prescription-only medicine (POM) in Kenya. Available at Pharmily with a valid prescription from a physician, diabetologist, cardiologist, or nephrologist.

Glysit 10mg is the therapeutic maintenance dose of Dapagliflozin, providing maximum glycaemic, cardiovascular, and renal benefit. Confirm eGFR at baseline; glycaemic efficacy diminishes below eGFR 45 ml/min, though the cardiorenal benefit extends to eGFR 25 ml/min.

Pre-surgical cessation counselling (minimum 3 days) and euglycaemic DKA awareness are the critical safety messages. The 28-tablet pack provides a 4-week supply; plan refill proactively to avoid treatment gaps.

For female patients, pre-emptive genital candidiasis counselling and hygiene advice improves adherence. Dapagliflozin at 10mg is the dose validated in the DAPA-HF and DAPA-CKD trials; confirm indication with prescriber if used for heart failure or CKD.

Q1: What is Glysit 10mg used for?

A: Glysit 10mg lowers blood sugar in Type 2 Diabetes and also protects the heart and kidneys. It is particularly recommended for people with both diabetes and heart or kidney disease.

Q2: Why does Glysit make me urinate more?

A: Glysit works by causing your kidneys to excrete excess glucose in urine, and extra water goes with it. This increased urination is normal and how the medicine works. Stay well hydrated.

Q3: What is euglycaemic DKA and why should I know about it?

A: It is a rare but serious condition where your blood becomes acidic even though blood sugar looks normal. Stop Glysit and seek emergency care if you have unexplained nausea, vomiting, stomach pain, or extreme fatigue.

Q4: Can Glysit 10mg protect my kidneys?

A: Yes, clinical trials (DAPA-CKD) showed that Dapagliflozin significantly slows the progression of chronic kidney disease, even in non-diabetic patients with kidney disease.